Question: In regards to patent 5344452, will this patent be eligible for renew after 2016? And if so under what conditions? Also, can this technology be used with a different plastic other than polymethly methacrylate, or is any similar microsphere implant devices protected? Is there a way to create something similar without violating the patent? if so what needs to be different?

Answer: Patents cannot be renewed. After expiration of the patent, you are free to use the patented invention.

However, there may be other patents that cover what you intend to make. Therefore, if you are concerned about infringing patents other than the 452 patent, you should conduct an infringement search.